Uses of Furosemide

Furosemide is a loop diuretic used to treat fluid retention (edema) in people with congestive heart failure, liver disease, or a kidney disorder such as nephrotic syndrome. Furosemide is also used to treat high blood pressure (hypertension).

Furosemide works by increasing the amount of urine the body makes, which helps reduce swelling and symptoms of fluid retention and helps lower high blood pressure. Furosemide tablets are sometimes called water pills as they increase how much you urinate.

Precautions and Warnings

Before using this medicine, tell your doctor if you have kidney disease, enlarged prostate, urination problems, cirrhosis or other liver disease, an electrolyte imbalance, high cholesterol, gout, lupus, diabetes, or an allergy to sulfa drugs.

Tell your doctor if you have recently had an MRI (magnetic resonance imaging) or any type of scan using a radioactive dye that is injected into your veins. Do not take more of this medication than is recommended.

If you are being treated for high blood pressure, keep using this medicine even if you feel fine. High blood pressure often has no symptoms.

Furosemide is a potent diuretic which, if given in excessive amounts, can lead to a profound diuresis with water and electrolyte depletion. Therefore, careful medical supervision is required and dose schedule must be adjusted to the individual patient’s needs

Tell your doctor about all your other medicines. Some drugs should not be used with furosemide.

It is not known if furosemide will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant.

It may not be safe to breastfeed while using furosemide. Ask your doctor about any risk. Furosemide may slow breast milk production.

Dosage

Oral: Initial dose: 20 to 80 mg orally once; may repeat with the same dose or increase by 20 or 40 mg no sooner than 6 to 8 hours after the previous dose until the desired diuretic effect has been obtained. Maintenance dose: Administer the dose that provided the desired diuretic effect once or twice a day (e.g., at 8 am and 2 pm).

Side Effects

Common side effects:

• diarrhea, constipation, loss of appetite;
• numbness or tingling;
• headache, dizziness; or
• blurred vision.

Side Effects: In the U. S. most people take no more than the indicated dose of furosemide per day. Most people do not experience any side effects.

Common side effects (rare):

• constipation, dizziness; or
• vomiting.

Uncommon side effects (signs changes):

• fainting or light-headedness.
• haemoconcentration.
• hypersensitivity to the active substance.

Some people may experience vomiting, diarrhea, or kidney problems while taking furosemide. Most side effects are mild and go away on their own. It is important to talk to your doctor before taking furosemide if you are taking:

acetaminophen (used to treat high blood pressure)

warfarin (used to prevent ulcers).

medicines such as anti-psychosis medications (used to treat psychosis)

antacids (used to prevent heartburn or heart surgery).

Low blood pressure can also occur with some medications. You should not increase your blood pressure with furosemide.

Symptoms of low blood pressure include:

• chills;
• low blood pressure with ankles or legs numb; or
• numbness or tingling.

• indigestion, stomach pain; or
• runny nose, indigestion, dizziness.

This is not a complete list of side effects. If you notice other effects not listed above, contact your doctor or pharmacist.

SUMMARY CMI

FUROSEMIDE

Consumer Medicine Information (CMI) summary

The on the next page has more details. If you are worried about using this medicine, speak to your doctor or pharmacist.

1. Why am I using FUROSEMIDE?

FUROSEMIDE contains the active ingredient furosemide.

For more information, see in the full CMI.

2. What should I know before I use FUROSEMIDE?

Do not use if you have ever had an allergic reaction to furosemide or any of the ingredients listed at the end of the CMI.

Talk to your doctor if you have any other medical conditions, take any other medicines, or are pregnant or plan to become pregnant or are breastfeeding.

4. How do I use FUROSEMIDE?

• Take FUROSEMIDE exactly as prescribed.
• Swallow one tablet whole with water.
• If you are being treated with furosemide, you will need to take a different dose or take it with food.
• If you need to take a diuretic (water pill), you will need to take a different dose or take it with water.

More instructions can be found in in the full CMI.

5. What should I know while using FUROSEMIDE?

Things you should do	Remind any doctor, dentist or pharmacist you visit that you are using FUROSEMIDE. Tell your doctor if you are pregnant, planning to become pregnant or breastfeeding.
Things you should not do	Do not stop taking FUROSEMIDE suddenly. Do not give FUROSEMIDE to anyone else, even if their symptoms seem similar to yours. Do not give FUROSEMIDE to anyone else with any of the following conditions:
Driving or using machines	FUROSEMIDE can cause dizziness. If you feel dizzy, you may need to drink more water. If you are dehydrated or have diarrhea, your doctor will prescribe fluids (such as water).
Drinking alcohol	FUROSEMIDE may cause low blood potassium levels. If you drink alcohol, you may have to drink more water, especially when standing up.
Looking after your medicine	Store at room temperature, away from moisture and heat.

6. Are there any side effects?

All medicines can have side effects.For more information, including what to do if you have any side effects, see in the full CMI.

Furosemide is a diuretic (water pill). Furosemide belongs to a group of medicines called loop diuretics. Loop diuretics help your body get rid of excess fluid and salt in the urine. By reducing the amount of salt in your body, these medicines help you urinate more easily.

Furosemide is used to treat hypertension (high blood pressure).

Furosemide is a loop diuretic. Loop diuretics help your body get rid of excess fluid and salt in the body.

The term 'loop diuretic' is used to change from a water pill to a salt pill. Loop diuretics are medicines that are released into your body when you are urinating.

References

1. KD. Tripathi. Diuretics. Essentials of medical pharmacology. Seventh edition. 2013. Page – 579-581.

2. Robert F. Reilley and Edwin K. Jackson. Regulation of renal function and vascular volume. Goodman & Gilman’s: The Pharmacological basics of Therapeutics. 12th Edition. New York McGraw Hill Medical 2011. Page – 682-686.

3. University of Pennsylvania. Furosemide for Accelerated Recovery of Blood Pressure Postpartum (ForBP). NIH U. S. National Library of Medicine ClinicalTrials.gov. [Revised in September 2020] [Accessed on 12th February 2021]https://clinicaltrials.gov/ct2/show/NCT03556761

4, Maria Rosa Ballester, Eulalia Roig, Ignasi Gich, Montse Puntes, Joaquin Delgadillo, Benjamin Santos and Rosa Maria Antonijoan. Randomized, open-label, blinded-endpoint, crossover, single-dose study to compare the pharmacodynamics of torasemide-PR 10 mg, torasemide-IR 10 mg, and furosemide-IR 40 mg, in patients with chronic heart failure. NCBI; PMC US National Library of Medicine, National Institute of Health. August 2015. [Accessed on 12th February 2021]https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4532344/

5. Elara Pharmaservices Limited. Electronic Medicines Compendium (EMC). [Revised in October 2020] [Accessed on 12th February 2021]https://www.medicines.org.uk/emc/files/pil.12129.pdf

6. Clonmel Healthcare Ltd. Health Products Regulatory Authority (HPRA). [Revised in December 2016] [Accessed on 12th February 2021]https://www.hpra.ie/img/uploaded/swedocuments/2188112. PA0126_008_002.fbf0465a-d44d-4c59-b51b-337dd8586c8e.000001Product%20Leaflet%20Approved.170215.pdf

All drugs used in the treatment of any disease are then subject to adverse drug reactions. This Code ofiler includes any indirect adverse drug reactions that may occur as a result of the treatments. If a patient requires a dose reduction or exchange of therapy, the dose that should be left to the next dose should be replaced.

Common side effects:

• abdominal pain
• flushing
• indigestion
• breast tenderness and enlargement
• vomiting
• reduced abdominal size

We would appreciate your information and permission to publish the drugs that have been studied in the COLD study and will be discussed with you before publication.

COLD is a study to help tens of thousands of people with chronic heart failure prevent heart failure by lowering their blood pressure.

The EMC (Elective Medical Drop) of COLD is a randomised, double-blind, parallel-group, placebo-controlled study to compare the pharmacodynamics of torasemide-PR 10 mg, torasemide-IR 10 mg, and furosemide-IR 40 mg, in patients with chronic heart failure.

This eligiblestudy is the first study to test the therapeutic therapeutic effect of torasemide-PR 10 mg, torasemide-IR 10 mg, and furosemide-IR 40 mg in patients with chronic heart failure. The study is a part of the ongoing UK Medicines and Health Products Regulatory Agency (MHRA) COLD programme. COLD is a multicentre, double-blind, placebo-controlled study to evaluate the therapeutic therapeutic effect of torasemide-PR 10 mg, torasemide-IR 10 mg, and furosemide-IR 40 mg in patients with chronic heart failure. The EMC of COLD is a randomised, parallel-group, placebo-controlled study to compare the pharmacodynamics of torasemide-PR 10 mg, torasemide-IR 10 mg, and furosemide-IR 40 mg, in patients with chronic heart failure.

Tablet - white to off white, flat, uncoated tablets with beveled edges, debossed ''I21A'' on one side and breakline on the other side.Therapeutic indications: Furosemide is a potent diuretic with rapid action. Furosemide tablets are indicated for:• The treatment of fluid retention associated with heart failure, including left ventricular failure, cirrhosis of the liver and renal disease, including nephrotic syndrome. • The treatment of mild to moderate hypertension when brisk diuretic response is required. Alone or in combination with other anti-hypertensive agents in the treatment of more severe cases.FeaturesNature and contents of container:• Polypropylene containers, with snap-on polythene lids, with integral tear-off security lids OR Glass bottles with screw caps with sternan faced liner: 1000, 500, 250, 100, 84, 70,54,42,28,21,15 and 14 tablets.• Blister strips (strips composed of aluminium foil and PVdC coated PVC film): 14, 15,21,28,42,56, 70 and 84 tablets. Special precautions for storage:• Container pack: Do not store above 25°C. Keep the container tightly closed.• Keep the container in the outer carton.• Bottle pack: Do not store above 25°C. Keep the bottle tightly closed. Keep the bottle in the outer carton.• Blister pack: Do not store above 25°C. Store in the original package in order to protect from light

BRUFSTRATIC USES: These are not a complete list of these drugs. There are many ways andfor some drugs it is necessary to choose a single: 1. Brandname or generic drugs: It is beneficial to identify which drugs are available at a particular price point in ordert choose the most appropriate one for your needs. 2.

Lasix 40mg tablet contains an active ingredient called Furosemide which belongs to the medication class known as diuretics. It is used to treat edema (excessive water accumulation) and high blood pressure. Edema can be caused by various underlying issues such as heart, lung, kidney, or liver problems. This helps the kidneys to remove excess water, which is not needed by the body.

Lasix 40mg tablet should not be taken if you are allergic to Furosemide or other sulphonamide-related medicines or any of the ingredients in the medication. Also, do not consume if you have anuria, impaired kidney function or kidney failure, severe kidney damage, very low levels of potassium, sodium, or other electrolytes, dehydration, low blood pressure, take potassium supplements or potassium-sparing diuretics, have liver cirrhosis or liver encephalopathy, suffer from Addison's disease, have digitalis poisoning, or if you are breastfeeding.

Before starting the treatment with Lasix 40mg tablet, notify your doctor if you have hypovolaemia (low blood volume) or risk of low blood pressure, hypoproteinaemia (low levels of blood protein) due to kidney damage, liver congestion or other liver problems, kidney problems, diabetes or insulin use, advanced age or medications that lower blood pressure, prostate issues or difficulty in urinating, history of gout or abnormal blood condition, and upcoming blood or urine tests.

It is not known how often or how to take it and if it is safe for you to use it for longer than recommended before starting treatment.

The most common side effects of the medication include headache, dizziness, drowsiness, volume loss, and muscle cramps. In rare cases, it can lead to kidney damage or interfere with your health. Your doctor may adjust the dosage or recommend spacing it out for a specific side effect. Inometers may be needed to allow more of the medicine to be taken.

Keep out of the reach of children

Ingredients:Each tablet contains sulphonamide HCl as the main ingredient. The other ingredients are: an antibiotic (Furosemide), anti-seizure medication (Simvastatin), anti-ulcer medications (Ampyi), and potassium-sparing diuretics (Ascorbic acid).